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Antidepressants That Interact With Psychedelic Medicine

To the best of our knowledge, this may be the most comprehensive analysis and review to date, on the chemico-biological interactions of these medicines in each of their respective drug classes. We explore the mechanisms by which antidepressants can reducing or amplifying the potency of a psychedelic trip, and the safety-first steps you can take to reduce negative interactions.

Selective serotonin reuptake inhibitors (SSRIs)

Citalopram (Celexa)

Escitalopram (Lexapro)

Fluoxetine (Prozac)

Fluvoxamine (Luvox)

Fluvoxamine CR (Luvox CR)

Paroxetine (Paxil)

Paroxetine CR (Paxil CR)

Sertraline (Zoloft)

Serotonin-norepinephrine reuptake inhibitors (SNRIs)

Desvenlafaxine (Pristiq)

Duloxetine (Cymbalta)

Venlafaxine (Effexor)

Venlafaxine XR (Effexor XR)

Milnacipran (Savella)

Levomilnacipran (Fetzima)

Serotonin partial agonist/reuptake inhibitor (SPARIs)

Vilazodone (Viibryd)

Vortioxetine (Trintellix)

 Tricyclic antidepressants (TCAs)

Amitriptyline (Elavil)

Desipramine (Norpramin)

Doxepin (Sinequan)

Imipramine (Tofranil)

Nortriptyline (Pamelor)


Clomipramine (Anafranil)

Maprotiline (Ludiomil)

Trimipramine (Surmontil)

Protriptyline (Vivactil)

Monoamine oxidase inhibitors (MAOIs)

Phenelzine (Nardil)

Selegiline (Emsam)

Tranylcypromine (Marplan)

Isocarboxazid (Parnate)


Norepinephrine-dopamine reuptake inhibitors (NDRIs)

Bupropion (Wellbutrin, Aplenzin)

Atypical agents

Mirtazapine (Remeron)

Nefazodone (Serzone)

Trazodone (Desyrel, Oleptro)

Buspirone (Buspar)

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